Read my (non-scientific) articles at Modern Parent and Change Your Mind Change Your Life at Medium
Celebrating my admission to the MSW 2-year program at the University of Toronto
A year ago, I gave myself permission to write the next chapter of my life as I want it. Then, I left my academic career and my life as I know it and I took a huge leap of faith. I applied to the University of Toronto Factor and Inwentash School of Social Work Master’s Program, to become a mental health practitioner. A wild dream of me.
I am overjoyed to receive the admission letter from the school and ready to become a grad student. (again!)
Read more on LinkedIn.
Read our scientific review article with Ana Maria Cuervo
Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone
A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machinery behind each of these types of autophagy.
2015 Doktora Başarı Ödülü Sahibini Buldu / 2015 Outstanding PhD award goes to…
23 Mart 2017
Moleküler Biyoloji, Genetik ve Biyomühendislik doktora programı mezunlarımızdan Ayşe Kumsal Tekirdağ bu yıl ilk defa verilmeye başlanan “Türkiye Moleküler Biyoloji Derneği Doktora Başarı Ödülü”nü aldı.
Celebrating Dr. Ayse Kumsal Tekirdag Kosar, Ph.D.
MICRORNA DEPENDENT CONTROL AND REGULATION MECHANISMS OF AUTOPHAGY IN HEALTH AND DISEASE
Autophagy is a cellular survival pathway that can be activated via different stresses and dysregulation of autophagy might result in pathological states. Therefore, the discovery of novel pathways regulating autophagy is crucial. miRNAs as non-protein-coding RNAs control cellular levels of genes and an unbiased screen carried out in Gozuacik laboratory revealed novel microRNAs regulating autophagy. During my PhD thesis, regulation of stress-induced autophagy through MIR376 family members and MIR181A were shown to be via targeting crucial autophagy genes: ATG4C, BECN1 and ATG5, respectively. Analysis of these miRNAs in terms their of i) effect on autophagic activity, ii) target prediction, and iii) target validation through various in vitro tests in different cancer cell lines were carried out during my PhD. Besides, the role of MIR376B in tumorigenesis has been under investigation to enlighten the role of MIR376B in the early stages of cancer formation in vivo. Altogether, the outcomes of my thesis are:1)Introduction of novel autophagy regulating miRNAs 2) Functional characterization of these miRNAs in the control of autophagic responses of cells and 3) Study of the role of autophagy regulating miRNAs in tumorigenesis in vitro and in vivo. Therefore, the discovery of miRNA-mediated regulation of autophagy which provides a dynamic mechanism under various stress conditions adds another layer of regulation for critical cell death and survival decisions in health and disease.