For selected publications click here.

x Corresponding author, * First authors with equal contribution.



Akkoc Y and Gozuacik Dx. MicroRNAs and autophagy. Biochimica Biophysica Acta (BBA)-Molecular Cell Research. Invited review in preparation.

Kocaturk NM, Akkoc Y, Kig C, Bayraktar O, Gozuacik D, Kutlu Ox. Autophagy as a molecular target for cancer treatment. European Journal of Pharmaceutical Sciences, 2019. In press.

Zuvin M, Kocak M, Unal O, Akkoc Y, Kutlu O, Yagci-Acar H, Gozuacik D, Kosar Ax. Nanoparticle Based Induction Heating at Low Magnitudes of Magnetic Field Strengths for Breast Cancer Therapy. Journal of Magnetism and Magnetic Materials, 2019. In press.

Ozbey A, Karimzadehkhouei M, Kocaturk NM, Erbil Bilir S, Kutlu O, Gozuacik D, Kosar Ax. Inertial focusing of Cancer Cell Lines in Curvilinear Microchannels. Micro and Nano Engineering, 2019. DOI: Link

Onal G, Kutlu O, Ozere E, Gozuacik D, Karaduman A, Dokmeci-Emre Sx. Impairment of Lipophagy by PNPLA1 Mutations Cause Lipid Droplet Accumulation in Primary Fibroblasts of Autosomal Recessive Congenital Ichthyosis Patients. Journal of Dermatological Science, 2019, 93(1): 50-57. Link

Akkoc Y, Lyubenova L, Grausgruber H, Janovská D, Yazici A, Cakmak Ix and Gozuacik Dx. Minor cereals exhibit superior antioxidant effects on human epithelial cells compared to common wheat cultivars.  Journal of Cereal Science, 2019, 85: 143-152. Link

Ozturk DG, Kocak M , Akcay A, Kinoglu K, Kara E, Buyuk Y, Kazan H and Gozuacik Dx. MITF/MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy, 2019, 15(3): 375-390. Link.

Ozturk DG, Kocak M, Gozuacik Dx. Cloning of Autophagy-Related MicroRNAs. Methods Mol Biol., 2019, 1854:131-146. doi: 10.1007/7651_2017_83. Link



Kocaturk N and Gozuacik Dx. Crosstalk between autophagy and the ubiquitin-proteasome system. Frontiers in Cell and Developmental Biology, 2018. Link

Vojo Dereticx, Eric Prossnitz, Mark Burge, Matthew J. Campen, Judy Cannon, Ke Jian Liu, Larry A. Sklar, Lee Allers, Sally Ann Garcia, Eric H. Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Gokhan Hotamisligil, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang & Daniel J. Klionsky. Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations.  Autophagy, 2018. DOI: 10.1080/15548627.2018.1465784.  Link

Altun E, Aydogdu MO, Koc F, Kutlu O, Gozuacik D, Yucel S, Gunduz Ox. Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning. BioNanoScience, 2018, p1-12, DOI: 10.1007/s12668-018-0539-y. Link

Akkoc Y and Gozuacik Dx. Autophagy and liver cancer. The Turkish Journal of Gastroenterology, 2018, DOI: 10.5152/tjg.2018.150318. Link.

Gozuacik Dx, Karakaş HE, Akkoç Y, Özata B. Otofaji ve kanser (Autophagy and cancer). In the book: Kanser Moleküler Biyolojisi (Cancer Molecular Biology). Yusuf Baran (Ed.).

Bayraktar Ox and Gozuacik D. The Crosstalk Between miRNAs and Autophagy in Cancer Progression. In: Fayyaz S., Farooqi A. (eds) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. pp 279-291. Springer Publishing, ISBN: 978-3-319-71553-7 / 978-3-319-71552-0. DOI: 10.1007/978-3-319-71553-7_15. Link

Boyd LS, Gozuacik D and Joubert AMx. The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma. Cellular & Molecular Biology Letters, 2018, 23:10. DOI: 10.1186/s11658-018-0079-z. Link

Yar Y, Khodadust R, Akkoc Y, Utkur M, Saritas EU, Gozuacik D, Yagci Acar Hx. Development of Tailored SPION-PNIPAM Nanoparticles by ATRP for Dually Responsive Doxorubicin Delivery and MR Imaging. Journal of Materials Chemistry B, 2018, 6, 289 – 300. Link

Ghorbani M, Alcan G, Sadaghiani AK, Mohammadi A, Unel M, Gozuacik D, Kosar Ax. Characterization and Pressure Drop Correlation for Sprays under the Effect of Micro Scale Cavitation. Experimental Thermal and Fluid Science,  2018, 91: 89-102. DOI: 10.1016/j.expthermflusci.2017.10.005. Link



Motezakker A, Sadaghiani AK, Akkoc A, Semsari Parapari S, Gozuacik D, Kosar Ax. Surface modifications for phase change cooling applications via crenarchaeon Sulfolobus solfataricus P2 biocoatings. Scientific Reports, 2017, 7 (17891). doi:10.1038/s41598-017-18192-2. Link

Erbil S, Kocaturk NM, Yayli M, Gozuacik Dx. Study of Protein-Protein Interactions in Autophagy Research. J Vis Exp. 2017 Sep 9;(127). doi: 10.3791/55881. Link

Onal G, Kutlu O, Gozuacik D and Dokmeci Emre Sx. Lipid Droplets in Health and Disease. Lipids in Health and Disease, 2017. 16: 128. DOI: 10.1186/s12944-017-0521-7. Link

Erbil-Bilir S, Gozuacik D, Kutlu Ox. Autophagy as a physiological response of the body to starvation. In the book: Handbook of Famine, Starvation, and Nutrient Deprivation: From Biology to Policy. Victor R. Preedy and Vinood B. Patel (Eds.). Springer Publishing, 2017. Link

Elitas Mx, Sadeghi S, Karamahmutoglu H, Gozuacik D and Turhal NS. Microfabricated platforms to quantitatively investigate cellular behavior under the influence of chemical gradients. Biomedical Physics & Engineering Express, 2017. 3(3): 035023. Link

Akgönül S, Özbey A, Karimzadehkhouei M, Gozuacik D, Ali Kosarx. The effect of asymmetry on micromixing in curvilinear microchannels. Microfluid Nanofluid, 2017. 21: 118. DOI 10.1007/s10404-017-1952-1. Link

Karakas HE*, Kim JY*, Park  J, Oh JM, Choi Y, Gozuacik Dx, Cho YKx. A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy inducing crosstalk in the stroma niche. Scientific Reports, 2017. 7(1):2050. doi: 10.1038/s41598-017-02172-7. Link
Kocaturk NM and Gozuacik Dx. Otofaji ve Nörodejeneratif Hastalıklar (Autophagy and Neurodegenerative Diseases). Turkiye Klinikleri J Pharmacol-Special Topics 2017;5(1):11-20. Link

Gozuacik Dx, Akkoc Y, Ozturk DG, Kocak M. Autophagy, MicroRNAs and Cancer. In the special issue: Self-eating on demand: Autophagy in Cancer and Cancer Therapy (Eds. Agostinis P and Lane J)Frontiers in Oncology, 2017. Link

Oral Ox,, Yedier O, Kilic S, Gozuacik D. Involvement of Autophagy in T Cell Biology. Histology and Histopathology, 2017, 32(1):11-20. Link



Ozbey A, Karimzadehkhouei M, Akgönül S, Gozuacik D, and Kosar Ax. Inertial Focusing of Microparticles in Curvilinear Microchannels (Circulating Tumor Cell (CTC) isolation biochip model). Scientific Reports, 2016, 6: 38809. Link

Bayraktar O, Oral O*, Kocaturk NM*, Akkoc Y, Eberhart K, Kosar A, Gozuacik Dx. IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation. PLoS One, 2016, 11(10): e0164864. Doi: 10.1371/journal.pone.0164864Link

Erbil S, Oral O*, Mitou G*, Cenk Kig, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik Dx. RACK1 is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. The Journal of Biological Chemistry, 2016, 291(32):16753-65. Link. 

Ghorbani M, Oral O, Ekici S, Gozuacik D, Kosar Ax. Review on Lithotripsy and Cavitation in Urinary Stone Therapy. IEEE Reviews in Biomedical Engineering. 2016, 9:264-83. Link

Ghorbani M, Yildiz M, Gozuacik DKosar AxCavitating Nozzle Flow in Micro- and Minichannels under the Effect of Turbulence. Journal of Mechanical Science and Technology, 2016,  30(6):2565–2581. Link

Tekirdag KA, Akkoc Y and Gozuacik Dx,. MIR376 family and cancer. Histology and Histopathology, 2016. Mar 4:11752.  Link

Ozlem Oralx, Yunus Akkoc, Gozuacik D. Physiological and Pathological Significance of Molecular Cross-talk Between Autophagy and Apoptosis. Histology and Histopathology. Histol Histopathology, 2015 Dec 18:11714. Link

Klionsky DJ et al. (International Autophagy Consortium including Gozuacik D). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy, 2016 Jan 2;12(1):1-222. Link



Demir F, Hocaoglu I,Ozturk DG, Gozuacik D, Kiraz A, Yagci Acar Hx. Highly Luminescent and Cytocompatible Cationic Ag2S NIR-emitting Quantum Dots for Optical Imaging and Gene Transfection. Nanoscale, 2015, DOI: 10.1039/C5NR00189G. Link

Ozbey A, Karimzadekhouie M, Yalcin SE, Gozuacik D, Kosar Ax. Modeling of ferrofluid magnetic actuation with dynamic magnetic fields in small channels (Preparatory tests for iron oxide nano particle magnetic manipulation cancer therapy). Microfluidics and Nanofluidics, March 2015, Volume 18, Issue 3, pp 447-460. Link

Uzusen D, Demir E, Perk OY, Oral O, Ekici O, Unel M, Gozuacik D, Kosar Ax. Assessment of probe-to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation. J. Med. Devices , 2015,  doi: 10.1115/1.4030274. Link

Oral Ox., Cıkım T, Zuvin M, Unal O, Yagci-Acar H, Gozuacik D, Kosar Ax. Effect of Varying Magnetic Fields on Targeted Gene Delivery of Nucleic Acid-Based Molecules. Annals of Biomedical Engineering, May 2015, DOI 10.1007/s10439-015-1331-6. Link

Gozuacik Dand Kig C. Cell death and autophagy: A historical perspective. In the book: Cell Death 1994-2014. Richard Lockshin and Zahra Zakeri (Eds.). An Anniversary Publication of the International Cell Death Society (ICDS). 2015. in press. Link

Arachiche A and Gozuacik DxAutophagy in health and disease. In the book: Toxicity and autophagy in neurodegenerative disorders. Jose Manuel Fuentes (Ed.). Springer Publishing. 2015. ISBN: 978-3-319-13938-8, Book chapter. Link

Tekirdag KA, Ozturk DG, Gozuacik DxRegulation of autophagy by miRNAs. In the book: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA (Ed.). Elsevier Academic Press. 2015. ISBN: 9780128010327, Book chapter. Link



Karakas HE and Gozuacik Dx. Autophagy and cancer. Turkish Journal of Biology, 2014, 38, (2014), 720-739. Link

Mehta R, Geckil H and Gozuacik D. Cancer: Normal cells’ reply to a deadly fate (Editorial). Turkish Journal of Biology, 2014, 38, (2014), 700. Link

Gozuacik Dx, Yagci-Acar HF, Akkoc Y, Kosar A, Dogan-Ekici AI, Ekici S. Anticancer use of nanoparticles as nucleic acid carriers. Journal of Biomedical Nanotechnology, 2014, September; 10(9): 1751-1783. Link

Kucukgul C, Ozler SB, Inci I, Karakas E, Irmak S, Gozuacik D, Taralp A, Koc B. 3D Bioprinting of Biomimetic Aortic Vascular Constructs with Self-Supporting Cells. Biotechnology and Bioengineering, 2014 Nov 11. doi: 10.1002/bit.25493. Link

Kurtoglu M, Kaya A, Gozuacik D, Yagci Acar HF, and Kosar Ax. Experimental study on convective heat transfer performance of iron oxide nanoparticle-based ferrofluids in microtubes (Preparatory tests for iron oxide nanoparticle hyperthermia therapy of cancer). ASME Journal of Thermal Science and Engineering Applications, 2014. Published online: doi:10.1115/1.4026490. Link

Cıkım T, Gozuacik D, Kosar Ax. Power reclamation efficiency of a miniature energy harvesting device using external fluid flows (Bio-inspired device). International Journal of Energy Research, 2014. Published online: DOI: 10.1002/er.3149. Link



Korkmaz G*, Tekirdag KA*, Ozturk DG, Kosar A, Sezerman OU and Gozuacik Dx. MIR376A is a regulator of starvation-induced autophagy. PLoS ONE, 2013, 8(12): e82556. doi:10.1371/journal.pone.0082556. Link

Tekirdag KA, Ozturk DG, Gozuacik DxAlterations in autophagic-lysosomal potential during ageing and neurological diseases: The miRNA perspective. Current Pathobiology Reports, 2013 December 2013, Volume 1, Issue 4, pp 247-261. Link

Itah Z*, Oral O*, Perk OY, Sesen M, Demir E, Erbil S, Dogan-Ekici AI, Ekici S, Kosar A, Gozuacik Dx. Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue. Experimental Biology and Medicine, 2013 November; 238(11): 1242-1250. Link

Tekirdag KA and Gozuacik Dx. Role of miRNAs in the regulation of autophagy. Pakistan Journal of Clinical and Biomedical Research, 2013. Jul-Dec 1(2): 6-10.

Eberhart K, Oral O, Gozuacik Dx. Induction of autophagic cell death by anticancer agents. pp 179-202. In the book: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA (Ed.). Elsevier Academic Press. 2013 ISBN: 9780124055308, Book chapterLink

Tekirdag AK*, Korkmaz G*, Ozturk DG, Agami R, Gozuacik Dx. miR-181a regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy, 2013 March; 9(3): 1-12. Link

Erzurumlu Y, Kose FA, Gozen O, Gozuacik D, Eric A. Toth EA, Ballar Px. A unique IBMPFD-related p97/VCP mutation with differential binding pattern and subcellular localization. The International Journal of Biochemistry & Cell Biology, 2013, Link



Oral O*,  Oz-Arslan D*, Itah Z, Naghavi A, Deveci R, Karacali S, Gozuacik Dx. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis, 2012 Aug; 17(8):810-20. Pubmed link

Klionsky DJ et al. (International Autophagy Consortium including Gozuacik D). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012 Apr;8(4):445-544. Pubmed link 

Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy, 2012 February; 8 (2): 165-176. Pubmed link

Kuzuoglu D, Cebeci Yalcinkaya O, Akpinar BA, Mitou G, Korkmaz G, Gozuacik D, Budak Hx. Autophagy-related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta, 2012, Oct;236(4):1081-92. Pubmed link

Perk OY, Sesen M, Gozuacik D, Kosar Ax. Kidney stone erosion by micro scale hydrodynamic cavitation and consequent kidney stone treatment. Annals of Biomedical Engineering, 2012, Sep; 40(9): 1895-902.  Pubmed link

Oral O, Irmak S, Ekici S, Gozuacik Dx . Ürolojide otofaji (Autophagy in urology). Pages: 271-283. In the book: Moleküler Üroloji (in Turkish). Türkeri L, Ozer A, Narter F, (Eds). 2012, Üroonkoloji Derneği Publishing. 2012. ISBN:978-975-01697-2-4. Book chapter.

Gözüaçık D. Otofaji ve sinyal yolakları (Autophagy and signaling pathways). Pages 49-60. In the book: Hücre ölümü araştırma teknikleri (In Turkish). Kocturk S, Vatansever  HS (Eds). Eskisehir Osmangazi University Press. 2012. ISBN No: 978-975-7936-95-4. Book chapter.

Gözüaçık D. Otofaji analiz yöntemleri ve uygulama aşamaları (Autophagy analysis techniques and applications). Pages 133-146. In the book: Hücre ölümü araştırma teknikleri (In Turkish). Kocturk S, Vatansever  HS (Eds). Eskisehir Osmangazi University Press. 2012. ISBN No: 978-975-7936-95-4. Book chapter.



Kosar A x, Sesen M, Oral O, Itah Z and Gozuacik Dx . Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications. IEEE Transactions on Biomedical Engineering, 2011 May;58(5):1337-46. Pubmed link

Öz-Arslan D, Korkmaz G, Gözüaçık Dx. Otofaji: Bir hücresel stres yanıtı ve ölüm mekanizması (in Turkish). Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2011 October; 2(4): 184-94. Review. PDF

Gözüaçık D. Otofaji ve sinyal yolakları (Autophagy and signaling pathways). Pages 53-61. In the book: Hücre ölümü araştırma teknikleri (In Turkish). Kocturk S, Vatansever  HS (Eds). Dokuz Eylul University Press. 2011. ISBN No: 978-975-441-349-6. Book chapter.

Gözüaçık D. Otofaji analiz yöntemleri ve uygulama aşamaları (Autophagy analysis techniques and applications). Pages 129-141. In the book: Hücre ölümü araştırma teknikleri (In Turkish). Kocturk S, Vatansever  HS (Eds). Dokuz Eylul University Press. 2011. ISBN No: 978-975-441-349-6. Book chapter.



Mitou G, Budak H, and Gozuacik D x . Techniques to Study Autophagy in Plants. International Journal of Plant Genomics, vol. 2009, Article ID 451357, 14 pages, 2009. doi:10.1155/2009/451357. Review. Pubmed link



Gozuacik D, Bialik S, RavehT, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death and Differentiation, 2008 15: 1875-86. Pubmed link



Gozuacik D and Kimchi A. Autophagy and cell death. Current Topics in Developmental Biology, 2007 78:217-45. Review.



Gozuacik D and Kimchi A. DAPk protein family and cancer. Autophagy, 2006 2(2): 74-79. Review.



Llambi F, Calheiros F, Gozuacik D, Pays L, Del Rio G, Kimchi A, Mehlen P. The dependence receptor UNC5H2 mediates apoptosis through DAP kinase. EMBO Journal, 2005 Mar 23;24(6):1192-201.



Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004 Apr 12;23(16):2891-906. Review.

Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A. Death- associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Molecular and Cellular Biology, 2004 Oct;24(19):8611-26.



Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene, 2003 Jun 19;22(25):3911-6.

Gozuacik D, ChamiM, Murakami Y, FaivreJ, LagorceD, Poch O, Biermann O, Knippers R, BréchotC, Paterlini-BréchotP. Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. Nucleic Acids Research, 2003 Jan 15;31(2):570-9.



Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot P. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene, 2001 Sep 27;20(43):6233-40.

Chami M*, Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. Journal of Cell Biology, 2001 Jun 11;153(6):1301-14.

Paterlini-Brechot P, Chami M and Gozuacik D. Calcium ATPase Genes and Cell Transformation. Pages 505-520. In the book: Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. Pochet R, Donato R, Haiech J, Heizmann CW, Gerk V (Eds.). Springer Publishing. 2001. ISBN: 0-7923-6421-X. Book chapter.



Chami M*, Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot P. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene, 2000 Jun 8;19(25):2877-86.

Brechot C, Gozuacik D, Murakami Y, Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Seminars in Cancer Biology, 2000 Jun;10(3):211-31. Review.


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