Research Themes

1. Nanoparticle-Enabled Drug Delivery

We are developing nano-delivery systems for cancer treatment. Our design goals are: high delivery efficiency, controlled release, target orientation, and biocompatibility. We correlate the physicochemical properties (size, surface charge, stability) of the carriers with treatment performance.

2. Microfluidics & Organ-on-Chip Models

We aim to model the tumor microenvironment, and treatment response more realistically with microfluidic organ-on-chip platforms. These systems allow us to evaluate candidate treatments quickly and quantitatively.

3. Field-Guided & Triggered Therapies

We are designing field-based modalities such as magnetic field guidance, hyperthermia, and tumor-treating fields to work in conjunction with drug delivery systems. Our goal is to optimize treatment not only through “delivery” but also through remotely controllable triggering.

4. Cavitation-Based Therapeutic Platforms

We are developing cavitation-based devices that temporarily increase cell membrane permeability, facilitate drug and nanoparticle uptake, and enhance localized therapeutic effects. By correlating cavitation parameters (frequency, amplitude, exposure time) with biological responses, we aim to create safe and reproducible treatment protocols.

5. Translational Evaluation & System Integration

We perform system integration in the device-treatment-model triangle. Experimental design, measurement standards, reproducibility, and scalability are fundamental components of our translational research approach.

 

 

METHODS / CAPABILITIES

• Nanoparticle synthesis, functionalization, and characterization
• Drug loading and controlled release analyses
• Cell culture-based efficacy and biocompatibility testing
• Microfluidic chip design and organ-on-chip prototyping
• Cavitation-based device design and validation
• Magnetic field, hyperthermia, and TTFields applications
• Quantitative and mechanism-based analysis of treatment response