Hüveyda Başağa

ARTICLES IN REFEREED JOURNALS

1. Meryem Ozlem Kutuk , Ali Evren Tufan, Zehra Topal, Ufuk Acikbas, Gulen Guler, Bahriye Karakas, Huveyda Basaga, Fethiye Kilicaslan, Ebru Altintas, Yeliz Aka and Ozgur Kutuk: CYP 450 and 2C19 genotypes in ADHD: not related with treatment resistance but with over-representation of 2C19 ultra-metabolizers. February 2022.
   Drug Metabolism and Personalized Therapy    https://doi.org/10.1515/dmpt-2021-0163
2. Ozgur Kutuk, Bahriye Karakas, Yeliz Aka, Asli Giray, Huveyda Basaga, Ufuk Acikbas, Ozgur Gul, and Sehime Gulsun Temel: Mitochondrial estrogen receptors alter mitochondrial priming and response to endocrine therapy in breast cancer cells. Cell Death Discovery, 7, 189 (1-14) 2021. Full text 
3. YelizAka, BahriyeKarakas, UfukAcikbas, HuveydaBasaga, OzgurGul, OzgurKutuk: Kinome wide RNAi screening for mediators of ABT_199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target. Int. J. of Biochem. and Cell Bio. 137, 106028, 2021. Full text 
   
4. Sehime Gulsun Temel, Aslı Giray, Bahriye Karakas, Ozgur Gul, Ilknur Kozanoglu, Husnu Celik, Huveyda Basaga, Ufuk Acikbas, Ceren Sucularli, Sidika Oztop, Yeliz Aka & Ozgur Kutuk; RAB 25 Confers resistance to chemotherapy by altering mitochondrial apoptosis in ovarian cancer cells. Apoptosis, 08 September 2020. Full text  
5. Yelda Birinci, Javed Niyazi, Oznur Aktay Cetin, Huveyda Basaga; Quercetin in the form of a nano-antioxidant (QTiO2) provides stabilization of quercetin and maximizes its antioxidant capacity in the mouse fibroblast model. Enzyme and Microbial Technology,2020 (138) 1-12.  https://authors.elsevier.com/a/1ayHaW49r4TVf
6. Arzu SAKUL, Mehmet OZANSOY, Birsen ELİBOL, Şule AYLA, Mehmet Yalçın GÜNAL, Yasemin YOZGAT,
   Hüveyda BAŞAĞA, Kazım ŞAHİN, Rümeyza KAZANCIOĞLU, Ülkan KILIÇ; Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice. Turkish Journal of Biology, 2019 (43), pages 1-10. Full text
7. Gina Manda1,a,*b, Mihail Eugen Hinescu1,2, Ionela Victoria Neagoe1, Luis Felipe Vieira Ferreira3, RicaBoscencu4, Paul Vasos5,6, Selma Huveyda Basaga7,8, and Antonio Cuadrado19,10,; Emerging Therapeutic Targets in Oncologic Photodynamic Therapy. Current Pharmaceutical Design, 2018;24(44):5268-5295. 
8. Beyza Vurusaner, Simona Gargiulo, Gabriella Testa, Paola Gamba, Gabriella Leonarduzzi, Giuseppe Poli and Huveyda Basaga; The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells. Redox Biology, Volume 17, July 2018, Pages 400-410. Full text.
9. Can Timuçin,  Huveyda Basaga, Ozgur Kutuk; Selective Targeting of Antiapoptotic BCL-2 Proteins in Cancer, Medicinal Research Reviews, invited review,Full text Med Res Rev 2018;1–30.
10. Bahriye Karakas; Yeliz Ozmay; Huveyda Basaga; Ozgur Gul; Ozgur Kutuk, MD, PhD; Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells. BBA Molecular Cell Research,in press. Volume 1865, Issue 8, August 2018, Pages 1073-1087. Full text
11. Rica Boscencu 1, Gina Manda 2,* ID , Natalia Radulea 1,*, Radu Petre Socoteanu 3,*,
    Laura Cristina Ceafalan 2, Ionela Victoria Neagoe 2, Isabel Ferreira Machado 4,5 ID ,
    Selma Huveyda Basaga 6,7 and Luís Filipe Vieira Ferreira 4; Studies on the Synthesis, Photophysical and
    Biological Evaluation of Some Unsymmetrical Meso-Tetrasubstituted Phenyl Porphyrins. Molecules 2017, 22, 1815; doi:10.3390/Full text
12. Ozgur Kutuk, Nurgul Aytan , Bahriye Karakas , Asli Giray Kurt, Ufuk Acikbas , Sehime Gulsun Temel, Huveyda Basaga; Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells. Plos One. Online Pub. (2017) Full text.
13. Ahmet Can Timucin & Huveyda Basaga; Pro-Apoptotic Effects of Lipid Oxidation Products: HNE at the crossroads of NF-κB Pathway and Anti-Apoptotic Bcl-2.  Free Radical Biology and Medicine. Volume 111, 7, Pages 209-218(2017). Full text.
14. Ahmet Can Timucin & Huveyda Basaga; SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights. Plos One. Online pub (2016). Full text.
15. Iulia Gabriela David & Mihaela Buleandră & Dana Elena Popa & Ana-Maria Cristina Bîzgan & Zenovia Moldovan & Irinel-Adriana Badea & Emilia Elena Iorgulescu & Tuğçe Ayça Tekiner & Huveyda Basaga; Voltammetric determination of polyphenolic content as rosmarinic acid equivalent in tea samples using pencil graphite electrodes. J Food Sci Technol. Online Pub  (2016). Full text
16. Beyza Vurusaner^a, Gabriella Leonarduzzi^b, Paola Gamba^b, Giuseppe Poli^b*, Huveyda Basaga^a,*;   Oxysterols and mechanisms of survival signaling.  Molecular Aspects of Medicine 49 (2016) 8–22. Full text
17. Beyza Vurusaner, PaolaGamba, SimonaGargiulo, GabriellaTesta, Erica Staurenghi, Gabriella Leonarduzzi, GiuseppePoli, Huveyda Basaga; Nrf2 antioxidant defense is involved insurvival signaling elicited by 27 hydroxycholesterol in human promonocytic cells. Free Radical Biology and Medicine 91(2016)93–104. Full text
18. Ahmet Can Timucin, Cagri Bodur, Huveyda Basaga; SIRT1 contributes to Aldose Reductase expression through modulating NFAT5 under osmotic stress: in vitro and in silico insights. Cellular Signalling. 27 (2015)2160-217. Online text.
19. Bodur Cagri; Karakas  Bahriye; Timucin  Ahmet; Tezil  Tugsan; Basaga  Huveyda; AMP-activated protein kinase couples 3-bromopyruvate induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins. Molecular Carcinogenesis. (2015). Full text .
20.  Marta Pajares, Natalia Jimenez-Moreno, Irundika H.K. Dias, Bilge Debelec, Milica Vucetic, Kari E. Fladmark, Huveyda Basaga, Samo Ribaric, Irina Milisav and Antonio Cuadrado; REDOX CONTROL OF PROTEIN DEGRADATION; Redox Biology. 6(2015)409–420. Full text.
21. Iulia Gabriela Davida, Ana-Maria Cristina Bizgana, Dana Elena Popaa, Mihaela Buleandraa, Zenovia Moldovana, Irinel Adriana Badea, Tuğçe Ayça Tekiner, Huveyda Basaga, Anton A. Ciucua: Rapid determination of total polyphenolic content in tea samples based on caffeic acid voltammetric behavior on a disposable graphite electrode; Food Chem. 173, Pages 1059–1065, 2015, . Full text.
22. Beyza Vurusaner, Paola Gamba, Gabriella Testa, Simona Gargiulo, Fiorella Biasi,Chiara Zerbinati , Luigi Iuliano , Gabriella Leonarduzzi , Huveyda Basaga, Giuseppe Poli: Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation; Free Radical Biology and Medicine, Free Radic Biol Med. 77:376-85, 2014 . Full text.
23. Tugsan Tezil and Huveyda Basaga: Modulation of cell death in age related diseases. Current Pharmaceutical Design, 20, 3052-3067, 2014. Full text
24. Tugce Ayca Tekiner and Huveyda Basaga: Role of microRNA deregulation in breast cancer cell chemoresistance and stemness. Current Medicinal Chemistry, 20, 27, 3358-3369, 2013. Abstract
25. Cagri Bodur, Ozgur Kutuk, Gizem Karsli-Uzunbas, Tayirjan T. Isimjan, Paul Harrison,Huveyda Basaga: Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling. PLoS ONE, 8, 2,1-13, 2013. Full text
26. C. Bodur and H. Basaga: Bcl-2 inhibitors; Emerging Drugs in Cancer Therapy, Current Medicinal Chemistry, 19, 1804-1820-2012. Full text
27. Tugsan Tezil, Cagri Bodur, Ozgur Kutuk, Huveyda Basaga: IKK-B mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death. Cellular Signalling, 24, 1361-1368, 2012. Full text
28. Cagri Bodur, Ozgur Kutuk, Tugsan Tezil, Huveyda Basaga: “Inactivation of Bcl-2 through I kappa B kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE). J. of Cellular Physiology, 19, 3556-65, 2012. Full text
29. Can Timucin , Ozgur Gul, Ozgur Kutuk, Huveyda Basaga: Antibody array based immunosensor for detecting cardiovascular disease markers. J.of Immunoassay and immunochemistry. 33: 275-290, 2012. Full text
30.  Vurusaner, B., Poli G., Basaga, H.: Tumor suppressor genes and ROS: Complex networks of interactions. Free Rad. Biol. Med. 52: 7-18 (2012). Full text
31. ANNE NEGRE-SALVAYRE 1 , NATHALIE AUGE 1 , VICTORIA AYALA 2 ,HUVEYDA BASAGA 3 , JORDI BOADA 2 , RAINER BRENKE 4 , SARAH CHAPPLE 5 ,GUY COHEN 6 , JANOS FEHER 7 , TILMAN GRUNE 8 , GABRIELLA LENGYEL 7 ,GIOVANNI E. MANN 5 , REINALD PAMPLONA 2 , GIUSEPPE POLI 9 ,MANUEL PORTERO-OTIN 2 , YAEL RIAHI 6 , ROBERT SALVAYRE 1 , SHLOMO SASSON 6 ,JOSE SERRANO 2 , OFER SHAMNI 6 , WERNER SIEMS 10 , RICHARD C. M. SIOW 5 ,INGRID WISWEDEL 11 , KAMELIJA ZARKOVIC 12 & NEVEN ZARKOVIC 13; Pathological aspects of lipid peroxidation, Free Radical Research,  44(10): 1125?1171; October 2010. Full text
32. Ozgur Kutuk; Sehime Gulsun Temel; Sahsine Tolunay; Huveyda Basaga; Aven blocks DNA damaged induced apoptosis by stabilizing Bcl-xl. European journal of Cancer. 46: 2494-2505 (2010). Full text
33. Arisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H. Small inhibitor of Bcl-2, HA14-1 selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat. 119:271-281, 2010. Abstract
34. Telci D, Collighan RJ, Basaga H, Griffin M. Increased TG2 expression can result in induction of TGF{beta}1 causing increased synthesis and deposition of matrix proteins which can be regulated by nitric oxide. J Biol Chem.  VOL. 284, NO. 43, pp. 29547?29558, 2009.
35. Kutuk, Ozgur; Arisan, Elif; Tezil, Tugsan; Shoshan, Maria; Basaga, Huveyda; Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa mediated lipid peroxidation. Carcinogenesis. vol.30 no.9 pp.1517?1527, 2009.full text
36. Hernlund E, Kutuk O, Basaga H, Linder S, Panaretakis T, Shoshan M. Cisplatin-induced nitrosylation of p53 prevents its mitochondria translocation. Free Radic Biol Med. 2009 Jun 15;46(12):1607-13. Abstract
37. Telci D, Li X, Elisabetta A. M. Verderio, Martin Humphries, Huveyda Basaga and Martin Griffin: Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem. 283(30):20937-20947, 2008. Abstract
38. Ozgur Gul, Huveyda Basaga and Ozgur Kutuk. Apoptotic blocks and chemotherapy resistance: Unraveling Bcl-2 protein network. Briefings in Functional Genomics and Proteomics. Feb. 18, 1-8, 2008. Abstract
39. Gul O, Calay E, Basaga H and Gurbuz Y. Sandwich ? type, Antibody Microarrays for Detection and Quantification of Cardiovascular Risk Markers, Sensors and Actuators B, 125, 581-588, 2007. Abstract
40. Kutuk O, Basaga H. Apoptosis Signalling by HNE; A Role For JNK-c-Jun/AP-1 pathway. Redox Report, 12: 30-35, 2007. Abstract
41. Kutuk O and Basaga H. Bcl-2 proteins and vascular apoptosis: Implications in atherosclerosis. Apoptosis, 11, 1661-1671, 2006 . Abstract
42. Arslan MA, Kutuk O and Basaga H. Protein Kinases as Drug Targets in Cancer, Current Cancer Drug Targets, 6, 623-634, 2006. Abstract
43. Kutuk O, Poli G and Basaga H. Resveratrol protects against 4-hydoxynonenal induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. Toxicological Sciences, 90(1), 120-132, 2006. Abstract
44. Arslan MA, Goktuna SI, Kutuk O and Basaga H Signaling pathways as drug targets in cancer. Advances in Molecular Medicine, suppl.vol1, April 2005 (national). Full text
45. Kutuk O, Pedrech A, Harrison P and Basaga H.:Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation. Apoptosis,10, 597-609, 2005. Abstract
46. Kutuk O and Basaga H. Aspirin inhibits TNFa- and IL-1-induced NF-kB activation and sensitizes HeLa cells to apoptosis. Cytokine, 25(5), 229-237, 2004. Abstract
47. Kutuk O and Basaga H. Inflammation meets oxidation: NF-kappa B as a mediator of initial lesion development in atherosclerosis. Trends in Molecular Medicine, vol 9 no12, 548-557, 2003. Abstract
48. Kutuk O, Adlı M, Poli G and Basaga H. Resveratrol protects against 4-hydroxynonenal-induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts. Biofactors,20,1-10, 2004. Abstract
49. Kutuk O and Basaga H. Aspirin prevents apoptosis and NF-kB activation induced by H2O2 in HeLa cells. Free Radical Research. vol 37 no 12, 1267-1276, 2003. Abstract
50. Arkan MC, Leonarduzzi G, Biasi F, Basaga H and Poli G. Physiological amounts of ascorbate potentiate phorbol ester induced nuclear binding of AP-1 transcription factor in cells of macrophagic lineage. Free Radicals in Biology and Medicine, vol. 31, no 3: 374-382, 2001. Abstract
51. Leonarduzzi G, Sevanian A, Sottero B, Arkan MC, Biasi F, Chiarpotto E, Basaga H and Poli G. Up-regulation of the fibrogenic cytokine TGF-ß by oxysterols: A mechanistic link between cholesterol and atherosclerosis. FASEB Journal, 15, 1619-1622, 2001. Full text
52. Leonarduzzi G, Arkan C, Basaga H, Chiaropotto A, Sevanian E, Poli G. Lipid Oxidation products in cell signaling. Free radicals in Biology and Medicine, 28, 9,1370-1378, 2000. Abstract
53. Onat D, Bosciboinik D, Azzi A, Basaga H. Effect of alpha-tocopherol and silibin dihemisuccinate on the proliferation of human skin fibroblasts. Biotechnol.Appl. Biochem. 29, 213-215, 1999. Abstract
54. Basaga HS, Poli G, Tekkaya C and Aras I. Free radical scavengingand antioxidative properties silibin complexes on microsomal lipid peroxidation. Cell Biochem. and Function. 15: 27-33, 1997. Abstract
55. Basaga HS, Tekkaya C and Açikel F. Antioxidative and free radical scavenging properties of rosemary extract. J. Food Science and Technology. 30, 105-108, 1997.
56. Basaga HS, Dik T. Effect of lactoperoxidase system on the activity of starter culture for yogurt production. Milchwissenschaft, 49: 3, 144-147, 1994.
57. Basaga HS, Geban Ö, Tekkaya C. The effect of instruction supplied with inquiry approach on biochemistry and science process skill achievements. Biochem. Ed. 22, 1, 29-32, 1994.
58. Poli G, Carini R, Comoglio A, Basaga HS, Albano E. Antioxidant and free radical scavenging properties of IdB 1016, a new flavanolignan complex. Eicosanoids and other bioactive lipids in cancer edited by Santoch Nigam, Lawrence J. Marnett, Kenneth V. Honn, Thomas L. Walden. Kluwer Academic Publishers, 1992.
59. Comoglio A, Leonarduzzi G, Carini R, Bussolin D, Basaga HS, Albano E, Tomassi A, Poli G, Morazzoni P and Magistretti MJ. Studies on the antioxidant and free radical scavenging properties of IdB 1016; a new flavanolignan complex. Free Rad. Res. Comms. 11, 109-115, 1990. Abstract
60. Basaga HS. Biochemical aspects of free radicals. Biochem.Cell Biol.68, 989-998, 1990. Abstract
61. Basaga HS. Free radical inactivation of proteins and protection by antioxidants. Turkish J. of Biochem. 3, 25-33, 1987.
62. Bahnemann D, Basaga HS, Dunlop JR, Searle AJF, Willson RL. Metronidazole, Misonidazole, iron, zinc and sulfur compounds in cancer. Brit.J. of Cancer, 37 supp. III, 14-17, 1978. Abstract
63. Basaga HS, Dunlop JR, Searle AJF, Willson RL. Metronidazole, Misonidazole, reduction by facultative anaerobes and cytotoxic action on hypoxic bacteria and mammalian cells in vivo. Brit. J. of Cancer, 37 Supp. III, 132-138, 1978.

BOOK CHAPTERS

1. Ozgur Kutuk and Huveyda Basaga. ?Apoptotic pathways in mitochondria? in Modern insights into disease from into insights into disease from molecules to man. Editor: Victor R. Preedy. 2009.
2. Ozgur Kutuk, Dilek Telci and Huveyda Basaga. ?Lipid peroxidation, gene expression and resveratrol; implications in atherosclerosis? in Phytochemicals, CRC Press. 2006.pp 61-82. Eds. Dr. Mark Meskin, Dr. Wayne Bidlack and Dr. Keith Randolph
3. Ozgur Kutuk and Huveyda Basaga. ?Phytoestrogens in cell signaling? in Phytoestrogens in Functional Foods, Taylor & Francis. October, 2005. pp 123-152. Eds. Yıldız F.,/Adlercreutz H.

REPORTS

1. TUSIAD ? Competitiveness strategies: Biotechnology report. December 2005.
2. TUSIAD ? Competitiveness strategies: Biotechnology report. March ? December, 2000.

PROCEEDINGS

1. Bodur C, Kutuk O, Poli G, Basaga H.: Role of Bcl-2 protein family members in 4-hydroxynonenal mediated apoptosis , Annual Meeting of the Society-for-Free-Radical-Research – Europe, AUG 26-29, 2009 Rome, Italy. Free Radical Research, 43, 34-34 Suppl. 1, 2009.
2. Gul O, Inceturkmen E, Kutuk O, Basaga H, Sezerman U and Gurbuz Y. Biosensor Implementation for Cardiovascular Risk Marker Analysis, IEEE Conference on Sensors, 2005.
3. Arkan M.C., Leonarduzzi G., Biasi F., Basaga H and Poli G. Ascorbate enhances PMA induced DNA binding of AP-1 through MAPK pathway. Proceedings of 11th Biannual meeting of SFRR Paris, France, July 16-22, 2002.
4. Kutuk O and Basaga H. ?Modulation of H2O2 and TNF-alpha induced Nf-KB activation by acetylsalicylic acid (Aspirin)? Proceedings of 11th Biannual meeting of SFRR Paris, France, July 16-22, 2002.