SIGNAL TRANSDUCTION AND GENE EXPRESSION: FROM MEMBRANE TO NUCLEUS

Functioning and regulation of gene expression is a fundamental question in current thinking in biology simply because such mechanisms can offer answers to cellular differentiation in molecular terms. A balance between signals that regulate cell proliferation, differentiation and programmed cell death controls normal development of multicellular organisms.

Dysregulation of any of these cellular processes can lead to a variety of human diseases, including cancer and atherosclerosis. Therefore signal transduction pathways from membrane to nucleus regulate gene expression patterns those determine the fate of a cell. Modulation of signal transduction involves changes at transcriptional, mRNA stability and post-translational levels.

APOPTOSIS REGULATION: LIVE OR LET DIE

Basaga?s Lab focuses on signal transduction pathways regulating apoptosis at molecular and cellular level.

Molecular and cellular biology techniques such as FACS, Immunoblot, Immunoprecipitation, Gene overexpression/silencing, Fluorescence microscopy, Fluorometric caspase assays, Gel filtration chromatography, M30-Apoptosense ELISA and Real-time PCR are currently being used in our laboratory. Optimization and development of high throughput target gene expression detection tools (cDNA microarrays) are currently being processed.

 

BIOTECHNOLOGY DEVELOPMENT IN TURKEY

Competitiveness strategies: Biotechnology report is an independent study conducted for TUSÄ°AD. It is known that the developments in BT will effect the whole world in the21th century and change the lives of millions of people both in developed and developing countries. Therefore, we aim to make an overview of BT from a wide perspective and is one of a series of reports written to increase the competitiveness of Turkish economy in order to maintain a steady and permanent position in the global economy.